KP Journal of Clinical and Medical Case Reports

Review Article

Cellular Signaling through the Use of Growth Factors and Mechanical Stimulus in Nerve Regeneration

Ezegbe Chekwube Andrew1,4,*, Amarachi Grace Ezegbe3#, Anikwe Celestine Chidera2, Odo Benjamin Kenechi1 and Juliana Marchi4

1Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Nigeria

2Department of Pharmaceutics, University of Hertfordshire, Hatfield, United Kingdom

3Department of Home Science and Management, University of Nigeria, Nsukka, Nigeria

4Human and Natural Science Center, ABC, Federal University, Santo Andre, Sao Paulo, Brazil

Received: September 20, 2024; Published: October 24, 2024

*Corresponding author: Ezegbe Chekwube Andrew, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Enugu, Nigeria & Federal University of ABC (UFABC), Center for Natural and Human Sciences, Santo Andre, Brazil

#Co-Corresponding author: Ezegbe Amarachi Grace, Department of Home Science and Management, University of Nigeria, Nsukka, Enugu State, Nigeria

Copyright: © 2024 Ezegbe Chekwube Andrew, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

DOI: 10.71205/KPJCMCR/1011

Abstract

The nervous system consist of the autonomous and peripheral. Peripheral nerve injury which occurs as a result of trauma, accident and other associated factors always results in a significant loss of sensory and motor functions in an individual. The injured nerves can be successfully restored although it requires a lot of complex cellular and molecular response in order to rebuild the functional axons. When this is achieved, the damaged nerve can accurately connect with their original targets. The complete recovery of PNI has not been optimized. Exogenous growth factors (GFs) is a new and emerging therapeutic strategy that can be used in nerve regeneration. The mechanism of action of growth factor is based on the ability to activate the downstream targets of various signaling cascades via binding to the individual receptors in order to exert the multiple effect and restore the neuron and tissue regeneration. Although the GFs are associated with short half-life and rapid deactivation in body fluids. The use of nerve conduits has been able to reduce the limitations. The nerve conduits have been good biocompatibility and biofunctionality properties.

Keywords

Growth Factors, Peripheral Nerve Injury, Signaling Cascade, Axons.

Citation: Andrew EC, et al. © (2024). Cellular Signaling through the Use of Growth Factors and Mechanical Stimulus in Nerve Regeneration. KP J Clin Med Case Rep. 2024; 3(1):1011